Preparation of 13-epi-Selamectin by Biotransformation Using a Blocked Mutant of Streptomyces avermitilis.
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چکیده
منابع مشابه
Erythronolide A glycosidation to erythromycin A by a blocked mutant of Streptomyces erythraeus.
The commonly accepted biosynthetic pathway1) leading to erythromycin A (I) requires that substrate for sugars (L-mycarose and Ddesosamine) attachment should be erythronolide B (IV). Once both sugars are linked to the aglycone, giving rise to erythromycin D, C-12 hydroxylation would occur resulting in erythromycin C production. Erythromycin C is further converted to erythromycin A by O-methylati...
متن کاملCharacterization of a silent sesquiterpenoid biosynthetic pathway in Streptomyces avermitilis controlling epi‐isozizaene albaflavenone biosynthesis and isolation of a new oxidized epi‐isozizaene metabolite
The genome-sequenced, Gram-positive bacterium Streptomyces avermitilis harbours an orthologue (SAV_3032) of the previously identified epi-isozizaene synthase (SCO5222) in Streptomyces coelicolor A3(2). The sav3032 is translationally coupled with the downstream sav3031 gene encoding the cytochrome P450 CYP170A2 analogous to SCO5223 (CYP170A1) of S. coelicolor A3(2), which exhibits a similar tran...
متن کاملproduction and screening of high yield avermectin b1b mutant of streptomyces avermitilis 41445 through mutagenesis
conclusions: the hereditary stability analysis of the uv mentioning 45 minutes revealed the uv exposure time for mutants and 3 represented the colony taken from the plate irradiated for 45 minutes mutant showed that the production of avermectin b1b remained constant and no reverse mutation occurred after 15 generations. results: avermectin b1b-hyper-producing mutant, produced using these three ...
متن کاملProduction and Screening of High Yield Avermectin B1b Mutant of Streptomyces avermitilis 41445 Through Mutagenesis
BACKGROUND Secondary metabolite production from wild strains is very low for economical purpose therefore certain strain improvement strategies are required to achieve hundred times greater yield of metabolites. Most important strain improvement techniques include physical and chemical mutagenesis. Broad spectrum mutagenesis through UV irradiation is the most important and convenient physical m...
متن کاملan investigation into translation of cultural concepts by beginner and advance student using think – aloud protocols
this research aims at answering the questions about translation problems and strategies applied by translators when translating cultural concepts. in order to address this issue, qualitative and quantitative study were conducted on two groups of subjects at imam reza international university of mashhad. these two groups were assigned as beginner and advanced translation students (10 students). ...
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ژورنال
عنوان ژورنال: The Journal of Antibiotics
سال: 2000
ISSN: 0021-8820,1881-1469
DOI: 10.7164/antibiotics.53.301